The focus of our research is placed on basic and translational studies of estrogen receptor (ER), a key molecule in breast cancer biology. We have developed a novel iSPOT platform (by integrating multi-biophysical techniques and computational docking) for modeling protein-protein complexes, and actively applied to the ER for discovering its allosteric signaling. Another area of focus is placed on understanding protein folding of the ER, responsible uniquely for cancer activation. Our research benefits from excellent computing facilities and synchrotron sources to which we have access, and close links with laboratories here at Cleveland and other parts of the globe.
Aug. 17, 2016: Good news on additional funds from the NIH! Many thanks!
Aug. 1, 2016: iSPOT is now published at Journal of Structural Biology!
October 1, 2015: A weblet for calculating Single-Residue Protection Factor is available online now!
August 1, 2015: We are awarded a 5-year NIH grant of $1.56M support, in addition to our current/previous support from DoE, DoD, and ACS. Big thanks to our team members!
Welcome! Yi and Corey joined our team.
Congratulations! Krishna is now Chief Scientific Officer of a new start-up at UC Davis.
Software: Fast-SAXS-pro, Single-Residue Protection Factor, and iSPOT
Teaching: Pharm528/BioC430