Our research is focused on biophysics and drug discovery of estrogen receptor (ER), a key driver for breast cancer growth. We have established an integrative multi-technique iSPOT platform for structure determination of protein-protein complexes. The application of iSPOT has uncovered a long-standing mystery about the inner-workings to the ER, critical for understanding the signaling from hormone activation to DNA binding. Another area of focus is placed on protein folding of an intrinsically-disordered domain of the ER, responsible uniquely for cancer activation. Our research benefits from excellent resources to which we have access, and close collaboration with laboratories here at Cleveland and other parts of the globe.
Aug. 17, 2016: Good news on additional funds from the NIH! Many thanks!
Aug. 1, 2016: iSPOT is now published at Journal of Structural Biology!
October 1, 2015: A weblet for calculating Single-Residue Protection Factor is available online now!
August 1, 2015: We are awarded a 5-year NIH grant of $1.56M support, in addition to our current/previous support from DoE, DoD, and ACS. Big thanks to our team members!
Congratulations! Krishna is now Chief Scientific Officer of a new start-up at UC Davis.
Software: Fast-SAXS-pro, Single-Residue Protection Factor, and iSPOT
Teaching: Pharm528/BioC430