The integrative-biophysics approach

Contemporary structural biology is entering an active period of new development, where integrative multi-technique approaches are emerging to tackle historically-challenging topics such as protein-protein interactions and intrinsically disordered proteins. Over the years, my lab has developed an integrative multi-technique method, termed iSPOT, combining multiple biophysical techniques and computational simulations. This integrative-biophysics approach has the built-in capability to integrate various sources of structural information (including but not limited to SAXS and NMR), providing the toolsets applicable to those protein-protein interactions and structural disorder that are of need for functional and disease-driven understanding.